If you're having issues with your audio or connectivity on macOS, we would recommend following the steps below to resolve the issue.
Are you using a USB hub? Sometimes this can interfere with the communication between the audio interface and computer. We'd recommend connecting directly (via USB) to the computer if possible. If you are using a USB hub, what make and model of hub are you using? I would also recommend trying every USB port and changing the USB cable.
In addition to this, to rule out corrupt system files, can you trash the audio preferences for your Mac. To do this, open the finder and navigate to Go Menu > Go to Folder. Into this box type type: /library/preferences/audio
When the folder opens, select the following .plist files from the audio folder and move them to the trash.
com.apple.audio.devicesettings.plist
com.apple.audio.systemsettings.plist
We also recommend deleting the Audio MIDI Preferences. These are found in a different preferences file that needs to be accessed in an alternative way:
To do this you would want to locate the Audio MIDI preferences files which can be found at: /Users/*Username*/Library/Preferences/com.apple.audio.AudioMIDISetup.plist(You may need to go to the Go menu in Finder and hold down the ALT key to get access to the User Library).
Then simply send the file to trash, then empty the trash and then reboot your iMac so the file can be re-written afresh. If any of the .pref files were corrupted then this should resolve the issue.
If this doesn't resolve the issue and you're on an Intel Mac, then try performing an NVRAM and SMC reset on your computer as this is what controls the communication between the software and hardware. Details on how to do this on your computer can be found here:
https://support.apple.com/en-gb/HT204063
https://support.apple.com/en-gb/HT201295
If these steps do not resolve your issue, please reach out to our support team who will be happy to assist further with this.